The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2017
Filed:
Sep. 16, 2013
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Universite Nice Sophia Antipolis, Nice, FR;
Patrick Collombat, Nice, FR;
Keith Al-Hasani, Nice, FR;
Monica Courtney, Nice, FR;
Nouha Ben-Ohtman, Nice, FR;
Elisabet Gjernes, Nice, FR;
Ahmed Mansouri, Goettingen, DE;
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, FR;
Centre National de la Recherche Scientific (CNRS), Paris, FR;
Universite Nice Sophia Antipolis, Nice, FR;
Abstract
The present invention relates to an in vitro or ex vivo method for producing a population of pancreatic beta-cells, comprising the step of inhibiting the expression or the activity of Arx in a population of pancreatic alpha-cells. The present invention also relates to method for inducing the conversion of pancreatic alpha-cells in pancreatic beta-cells in a patient in need thereof.