The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
Dec. 23, 2015
Applicants:
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Centre National DE LA Recherche Scientifique, Paris, FR;
Universite DE Nice Sophia Antipolis-grand Château, Nice, FR;
Inventors:
Jacob Hecksher-Sørensen, Bagsværd, DK;
Patrick Collombat, Nice, FR;
Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/39 (2006.01); A61K 31/197 (2006.01); A61K 45/06 (2006.01); A61K 35/39 (2015.01); C12N 5/071 (2010.01); C07K 16/26 (2006.01); A61K 39/00 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/197 (2013.01); A61K 35/39 (2013.01); A61K 39/00 (2013.01); A61K 45/06 (2013.01); C07K 16/26 (2013.01); C12N 5/0676 (2013.01); A61K 31/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C12N 2501/335 (2013.01); C12N 2501/845 (2013.01); C12N 2506/22 (2013.01);
Abstract
The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy.