Patricia Ohana

Title: Patricia Ohana: Innovator in Liposomal Drug Delivery

Introduction

Patricia Ohana is a prominent inventor based in Jerusalem, Israel, known for her significant contributions to the field of pharmaceutical sciences. With a total of four patents to her name, she has focused her research on innovative drug delivery systems, particularly utilizing liposomal technology.

Latest Patents

Among her latest patents is a liposome composition comprising a liposomal prodrug of mitomycin C and a method of manufacture. This invention describes a liposome composition that includes a lipophilic prodrug of mitomycin C, which boasts an improved pharmacokinetic profile. The method for preparing this composition involves a solvent system made up of ethanol and tertiary butanol mixed in an adequate ratio. In one embodiment, the liposome composition consists of a population of lipid nanoparticles, which includes a first fraction of spherical liposomes and a second fraction of rod-shaped lipid nanoparticles, where the latter constitutes less than about 15% of the total population.

Another notable patent is the liposome composition co-encapsulating doxorubicin and a prodrug of mitomycin C. This composition features liposomes with a lipid layer that defines an internal aqueous compartment, where an anthracycline drug is entrapped in the internal aqueous phase, and the mitomycin C prodrug is incorporated into the lipid layer.

Career Highlights

Patricia has worked with several notable companies in the pharmaceutical industry, including Lipomedix Pharmaceuticals Ltd. and Shaare Zedek Scientific Ltd. Her work has significantly advanced the development of liposomal drug delivery systems, which are crucial for enhancing the efficacy and safety of cancer treatments.

Collaborations

Throughout her career, Patricia has collaborated with esteemed colleagues, including Alberto Gabizon and Hilary Shmeeda. These collaborations have further enriched her research and contributed to the success of her innovative projects.

Conclusion

Patricia Ohana's work in liposomal drug delivery exemplifies the impact of innovative research in the pharmaceutical field. Her patents reflect a commitment to improving therapeutic outcomes for patients, particularly in cancer treatment.