Company Filing History:
Years Active: 2016-2022
Title: Innovations in Antibiotic Development by Patricia Miller
Introduction
Patricia Miller is a notable inventor based in South Bend, IN (US), recognized for her contributions to the field of antibiotic research. With a total of 3 patents, she has made significant strides in developing new antibacterial compounds that address critical health concerns.
Latest Patents
Her latest patents include groundbreaking work on antibacterial monobactams. This patent details the bromine-induced lactamization of vinyl acetohydroxamates, which facilitates the synthesis of monocyclic β-lactams. These compounds are designed for the incorporation of thiomethyl and extended functionality at the C(4) position. The resulting substituted N-hydroxy-2-azetidinones have shown promise in enhancing antibiotic activity. Evaluation of their antibacterial efficacy against a range of Gram-positive and Gram-negative bacteria has revealed important structure-activity relationships (SAR) and identified potent new monobactam antibiotics. Another significant patent focuses on antibacterial sideromycins, which comprise an Fe(III)-binding siderophore and daptomycin, aimed at improving the treatment of infections caused by resistant bacterial strains.
Career Highlights
Patricia has worked with esteemed institutions such as the University of Notre Dame Du Lac and Hsiri Therapeutics, Inc. Her research has been pivotal in advancing the understanding and development of new antibiotics, particularly in the face of rising antibiotic resistance.
Collaborations
Throughout her career, Patricia has collaborated with notable colleagues, including Marvin J. Miller and Cheng Ji. These partnerships have contributed to her innovative research and the successful development of her patented technologies.
Conclusion
Patricia Miller's work exemplifies the critical role of innovation in the fight against antibiotic resistance. Her patents and research efforts continue to pave the way for new treatments that can effectively combat bacterial infections.