Paranji Ramaiyenger Narayanan

Title: Innovations of Paranji Ramaiyenger Narayanan

Introduction

Paranji Ramaiyenger Narayanan is a notable inventor based in Chennai, India. He has made significant contributions to the field of biotechnology, particularly in the development of mutant strains for medical research. His work focuses on the modification of tyrosine phosphatase genes, which has implications for understanding virulence and pathogenesis in mycobacteria.

Latest Patents

Narayanan holds a patent for a method that provides mutant strains harboring a modified tyrosine phosphatase gene (mptpA or mptpB). This invention details a process for developing mutant strains that are incapable of expressing active tyrosine phosphatase. The method includes modifying the mptpA or mptpB gene by replacing internal sequences with an antibiotic resistance marker gene. This disruption leads to the inability to express the active gene. Furthermore, the invention encompasses a recombinant vector comprising the modified mptpA or mptpB, which can be utilized to develop mutant strains of mycobacteria. This research is crucial as it assesses the role of tyrosine phosphatases MptpA and MptpB, which can serve as potential targets for developing anti-tubercular drugs.

Career Highlights

Throughout his career, Narayanan has worked with esteemed institutions such as the Indian Council of Medical Research and the University of Delhi. His research has contributed to advancements in medical science, particularly in the fight against tuberculosis.

Collaborations

Some of his notable coworkers include Anil Kumar Tyagi and Ramandeep Singh. Their collaborative efforts have furthered research in the field of biotechnology and medical applications.

Conclusion

Paranji Ramaiyenger Narayanan's innovative work in biotechnology and his patent on mutant strains highlight his contributions to medical research. His efforts pave the way for potential advancements in anti-tubercular drug development.