The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2011
Filed:
Jul. 09, 2004
Anil Kumar Tyagi, New Delhi, IN;
Ramandeep Singh, New Delhi, IN;
Vivek Rao, New Delhi, IN;
Vadakkuppattu Devasenapathi Ramanathan, Chennai, IN;
Chinnambedy Nainarappan Paramasivan, Chennai, IN;
Paranji Ramaiyenger Narayanan, Chennai, IN;
Yogendra Singh, Delhi, IN;
Anil Kumar Tyagi, New Delhi, IN;
Ramandeep Singh, New Delhi, IN;
Vivek Rao, New Delhi, IN;
Vadakkuppattu Devasenapathi Ramanathan, Chennai, IN;
Chinnambedy Nainarappan Paramasivan, Chennai, IN;
Paranji Ramaiyenger Narayanan, Chennai, IN;
Yogendra Singh, Delhi, IN;
Indian Council of Medical Research, New Delhi, IN;
University of Delhi, New Delhi, IN;
Abstract
The present invention provides mutantstrains harboring a modified tyrosine phosphatase gene (mptpA or mptpB) wherein the mutantstrain is incapable of expressing the active tyrosine phosphatase. The invention provides a method for developing the said mutant strain from eitheror. The mptpA or mptpB gene may be modified by replacing the internal sequences with an antibiotic resistance marker gene, which disrupts the expression of the active gene. The invention further provides a recombinant vector comprising the modified mptpA or mptpB which may be used to develop the mutant strains of mycobacteria. The invention provides a method to assess the role of tyrosine phosphatases MptpA and MptpB in the virulence and pathogenesis ofwhich can be used as potential targets for developing anti-tubercular drug.