This inventor holds 3 USPTO granted patents, plus 1 CIPO patent. Top assignees: Aureon Laboratories, Inc., Aueron Laboratories, Inc.. Active years: 2006-2011.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2006-2011
Title: Paola Capodieci: Innovator in Diagnostic Histopathology
Introduction
Paola Capodieci is a prominent inventor based in New York, NY (US). She has made significant contributions to the field of diagnostic histopathology, holding a total of 3 patents. Her work focuses on innovative methods for detecting nascent RNAs and mRNA transcripts in tissue samples.
Latest Patents
One of her latest patents is titled "Diagnostic histopathology using multiplex gene expression FISH." This invention relates to a method for detecting one or more nascent RNAs in a tissue sample using fluorescence in situ hybridization (FISH). The method employs a plurality of probes, ranging from 8 to 82, to detect a single species of nascent RNA. Additionally, it allows for the simultaneous detection of multiple nascent RNA species using the same number of probes. The invention also includes methods for preparing samples to reduce autofluorescence, which significantly improves detection results.
Another notable patent is "Methods and compositions for the preparation and use of fixed-treated cell-lines and tissue in fluorescence in situ hybridization." This invention focuses on detecting mRNA transcripts in paraffin-embedded tissue through a process known as 'mRNA liberation in fixed-treated tissue' or 'MLIFTT'. The method involves treating the tissue with ammonia-ethanol and sodium borohydride, combined with pressure cooking, to reduce autofluorescence and overcome fixation-induced chemical bond interference. This innovative approach can identify multiple mRNA transcripts in a microarray format.
Career Highlights
Paola has worked with notable companies such as Aureon Laboratories, Inc. and Aueron Laboratories, Inc. Her expertise in histopathology and molecular biology has positioned her as a leader in her field.
Collaborations
Throughout her career, Paola has collaborated with esteemed colleagues, including Jon Edelson and Michael Donovan. These partnerships have furthered her research and contributed to her innovative developments.
Conclusion
Paola Capodieci is a trailblazer in the field of diagnostic histopathology, with a focus on innovative methods for RNA detection. Her contributions through her patents and collaborations have significantly advanced the understanding and capabilities in this area.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile