This inventor holds 1 USPTO granted patent. Top assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services. Active years: 2022.
Company Filing History:
Years Active: 2022
Title: The Innovative Contributions of Paejonette Jacobs
Introduction
Paejonette Jacobs is a notable inventor based in the Bronx, NY (US). He has made significant contributions to the field of hematopoietic stem cell research. His innovative work focuses on enhancing the engraftment of these cells, which is crucial for successful transplantation procedures.
Latest Patents
Paejonette Jacobs holds a patent for "Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells." This patent outlines methods for improving the engraftment of hematopoietic stem cells (HSC) in recipient subjects by reducing the expression or activity of CXC chemokine receptor 4 (CXCR4). The methods described can be utilized in gene therapy protocols and HSC transplantation, allowing procedures to occur without the need for radiation or chemotherapy conditioning, which is typically required in non-myeloablative HSC transplants. In some instances, gene editing techniques are employed to delete one copy of the CXCR4 gene prior to HSC or bone marrow transplantation, thereby enhancing the efficiency and durability of donor cell repopulation.
Career Highlights
Paejonette Jacobs is affiliated with the United States of America, as represented by the Secretary, Department of Health and Human Services. His work has been instrumental in advancing the understanding and application of stem cell therapies.
Collaborations
Paejonette Jacobs has collaborated with esteemed colleagues such as Harry L Malech and Joy Liu. Their combined expertise has contributed to the success of various research initiatives in the field of hematopoietic stem cells.
Conclusion
Paejonette Jacobs is a pioneering inventor whose work in enhancing hematopoietic stem cell engraftment has the potential to transform transplantation practices. His innovative approaches and collaborations continue to push the boundaries of medical science.