The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2022
Filed:
Jul. 17, 2015
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Jiliang Gao, Potomac, MD (US);
Philip M. Murphy, Rockville, MD (US);
David H. McDermott, Olney, MD (US);
Marie Siwicki, Washington, DC (US);
Harry L. Malech, Bethesda, MD (US);
Joy Liu, Boyds, MD (US);
Paejonette Jacobs, Bronx, NY (US);
Abstract
Provided herein are methods of enhancing engraftment of hematopoietic stem cells (HSC) in recipient subjects by reducing expression (or activity) of CXC chemokine receptor 4 (CXCR4). Such methods can be used in gene therapy protocols and in HSC transplantation, for example allowing this to occur without radiation or chemotherapy conditioning as is typically done in non-myeloablative HSC transplant. In some examples, gene editing methods are used to delete one copy of the CXCR4 gene before HSC or bone marrow transplantation, enhancing the efficiency and durability of donor cell repopulation.