Location History:
- Oyama, JP (1994 - 1997)
- Saitama, JP (1996 - 2001)
- Minamikawachimachi, JP (2007)
- Tochigi, JP (2005 - 2009)
Company Filing History:
6 out of 613 
5 out of 200 
3 out of 440 
Years Active: 1994-2009
Title: Nobuyuki Shima: Innovator in Bone Disease Treatment
Introduction
Nobuyuki Shima is a distinguished inventor based in Tochigi, Japan, recognized for his significant contributions to the field of biomedical research. With a robust portfolio of 14 patents, his work primarily focuses on innovations aimed at treating bone diseases. His dedication to advancing medical science has positioned him as a noteworthy figure in the realm of therapeutic development.
Latest Patents
Shima's latest patents include groundbreaking methods for reducing bone absorption. One such innovation involves the administration of antibodies that bind to OBM, alongside novel proteins and polypeptides known to influence osteoclastogenesis. These OCIF-binding molecules, or OBMs, represent a significant leap in understanding and mitigating bone diseases. Additionally, his patents detail processes for producing these innovative proteins and nucleic acid molecules through genetic engineering, providing vital tools for medical advancement. The medicinal compounds he developed incorporate these proteins and nucleic acids and target the treatment of various bone conditions.
Another pivotal patent outlines a protein that inhibits osteoclast differentiation and maturation. This protein is produced from human embryonic lung fibroblasts, showcasing complex molecular weights depending on the conditions under which it is analyzed. The methods Shima has patented for isolating and purifying this protein from fibroblast culture medium highlight his engineering capabilities. Furthermore, his patents include the cDNA necessary to produce this protein via gene engineering, along with specific antibodies designed for precise protein detection.
Career Highlights
Throughout his career, Nobuyuki Shima has collaborated with notable companies, such as Sankyo Company, Limited, and Snow Brand Milk Products Co., Ltd. His work at these institutions has enabled him to expand his research and apply his innovative ideas in real-world applications. Shima's 14 patents not only underscore his inventive spirit but also reflect his commitment to developing effective treatments for bone diseases.
Collaborations
In the course of his career, Shima has worked alongside esteemed colleagues, including Kanji Higashio and Eisuke Tsuda. These collaborations have fostered a creative environment that stimulates innovation and enhances research outcomes. Together, they have significantly contributed to the understanding of osteoclastogenesis and the development of targeted therapeutic strategies.
Conclusion
Nobuyuki Shima's contributions to the field of medicine through his innovative patents emphasize the importance of research and collaboration in tackling complex health challenges. His work paves the way for advancements in treating bone diseases, providing hope and improved treatment options for patients. As an influential inventor, Shima continues to inspire future innovations in biomedical science.