The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2007
Filed:
Feb. 25, 2004
Masaaki Goto, Tochigi, JP;
Eisuke Tsuda, Tochigi, JP;
Shin'ichi Mochizuki, Tochigi, JP;
Kazuki Yano, Tochigi, JP;
Fumie Kobayashi, Tochigi, JP;
Nobuyuki Shima, Tochigi, JP;
Hisataka Yasuda, Tochigi, JP;
Nobuaki Nakagawa, Tochigi, JP;
Tomonori Morinaga, Tochigi, JP;
Masatsugu Ueda, Kawagoe, JP;
Kanji Higashio, Kawagoe, JP;
Masaaki Goto, Tochigi, JP;
Eisuke Tsuda, Tochigi, JP;
Shin'ichi Mochizuki, Tochigi, JP;
Kazuki Yano, Tochigi, JP;
Fumie Kobayashi, Tochigi, JP;
Nobuyuki Shima, Tochigi, JP;
Hisataka Yasuda, Tochigi, JP;
Nobuaki Nakagawa, Tochigi, JP;
Tomonori Morinaga, Tochigi, JP;
Masatsugu Ueda, Kawagoe, JP;
Kanji Higashio, Kawagoe, JP;
Sankyo Co., Ltd., Tokyo, JP;
Abstract
A protein which inhibits osteoclast differentiation and/or maturation and a method of production of the protein. The protein is produced by human embryonic lung fibroblasts and has molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis, respectively. The protein can be isolated and purified from culture medium of the said fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity to the protein or a method for determination of the protein concentration using the antibodies.