Chigasaki, Japan

Nobuo Shimma



Average Co-Inventor Count = 6.5

ph-index = 9

Forward Citations = 412(Granted Patents)


Location History:

  • Kamakura, JP (2011 - 2013)
  • Chigasaki, JP (1989 - 2021)
  • Kanagawa, JP (1995 - 2022)

Company Filing History:


Years Active: 1989-2022

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35 patents (USPTO):

Title: Innovator Spotlight: Nobuo Shimma

Introduction: Nobuo Shimma, a prolific inventor based in Chigasaki, Japan, holds an impressive portfolio of 35 patents. His groundbreaking work primarily focuses on medical applications, particularly concerning the regulation and treatment of diseases linked to adenosine monophosphate-activated protein kinase (AMPK) dysregulation.

Latest Patents: Among his latest innovations are two notable patents. The first is a combination therapy utilizing an ascochlorin derivative designed to treat or prevent conditions involving AMPK dysregulation, especially various forms of cancer. This invention incorporates a unique compound presented by a specific formula along with an immune checkpoint inhibitor, promising a potent therapeutic approach. The second patent presents a novel ascochlorin derivative that acts as an AMPK activator, intended for treating or preventing diseases linked to AMPK dysregulation. This patent details a compound formulated for pharmaceutical applications, contributing further to the therapeutic landscape.

Career Highlights: Nobuo Shimma has significantly impacted the pharmaceutical field, collaborating with prestigious companies such as Chugai Pharmaceutical Co., Ltd. and Hoffmann-La Roche Inc. His career reflects a commitment to innovation and the advancement of medical treatments, underscoring the importance of intellectual property in enabling research and development.

Collaborations: Throughout his career, Shimma has worked alongside notable colleagues, including Isao Umeda and Takuo Tsukuda. Their collaborative efforts have fostered an environment of creativity and scientific exchange, driving forward important research initiatives.

Conclusion: Nobuo Shimma stands out as a vital contributor to the field of biotechnology and pharmaceuticals with his innovative approaches to addressing AMPK-related diseases. His patented inventions not only highlight the importance of intellectual property in fostering innovation but also exemplify the potential for research to translate into impactful medical treatments. The work of inventors like Shimma is crucial for advancing health solutions and improving patient outcomes globally.

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