Company Filing History:
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Years Active: 1988-1997
Title: The Innovative Journey of Noboru Tomioka
Introduction
Noboru Tomioka, a distinguished inventor hailing from Mobara, Japan, has made significant contributions to the field of biotechnology. With a repertoire of four patents, his innovative work primarily focuses on advancements in genetic engineering and protein production.
Latest Patents
Tomioka's latest patents showcase his pioneering efforts in the realm of molecular biology. One notable patent involves a DNA base sequence that encompasses regions crucial for the production of proteins. Specifically, he has cloned a neutral protease gene from Bacillus amyloliquefaciens, which includes the promoter region, ribosome binding region, secretion region, structural gene region, and terminator region. This composite DNA sequence is essential for constructing recombinant DNA that facilitates the production of proteins through the culturing of host bacteria, such as B. subtilis, transformed with the recombinant DNA, leading to large-scale extracellular production of neutral protease.
Another significant patent addresses an animal cell transformant methodology. This innovative technique allows for the introduction of a wild-type DHFR gene along with a structural gene that codes for a desired useful substance into wild-type animal cells. By employing a medium containing methotrexate at controlled concentrations, Tomioka has demonstrated effective amplification of both genes within an MTX-resistant strain, yielding a stable amplified transformant. This breakthrough allows for the consistent production of high yields of the desired foreign gene product.
Career Highlights
Throughout his career, Noboru Tomioka has been associated with prominent organizations, including the Agency of Industrial Science and Technology and the Ministry of International Trade and Industry. His tenure at these institutions has allowed him to drive research initiatives and contribute to Japan's technological advancements in various sectors, particularly in biotechnology.
Collaborations
Tomioka has also collaborated with esteemed colleagues, including Yoshio Furutani and Masaru Honjo. Their partnerships have undoubtedly enriched his projects and fostered an environment of innovation and creativity within the industry.
Conclusion
Noboru Tomioka's inventive spirit and dedication to advancing biotechnology have led to significant breakthroughs in recombinant DNA technology and protein production. With his noteworthy patents and impactful collaborations, he continues to influence the landscape of modern scientific development, leaving a lasting legacy in the field of innovations.