Nigel Paul Michael

Title: Innovations and Contributions of Inventor Nigel Paul Michael

Introduction

Nigel Paul Michael is a notable inventor based in Amersham, GB. He has made significant contributions to the field of fluorescent detection methods and proteins. With a total of 4 patents to his name, his work has advanced the understanding and application of fluorescence in various scientific contexts.

Latest Patents

One of his latest patents is a method for increasing the fluorescence of a Cyanine dye molecule. This method involves the reduction of a NO group to NHOH or NH by the action of a nitroreductase. The cyanine dye molecule can be utilized as a substrate for detecting nitroreductase enzyme activity, which allows for the use of this enzyme in an enzyme-reporter system for detecting analytes, binding reactions, or gene expression. Another significant patent involves engineered derivatives of green fluorescent protein (GFP). These modified GFPs exhibit enhanced fluorescence when expressed in non-homologous cells at elevated temperatures. This innovation greatly improves the utility of fluorescent proteins in studying cellular functions in living cells.

Career Highlights

Throughout his career, Nigel has worked with prominent companies such as GE Healthcare UK Limited and Amersham Plc. His experience in these organizations has contributed to his expertise in the field of fluorescence and detection methods.

Collaborations

Nigel has collaborated with notable individuals in his field, including Nicholas Thomas and Simon Lawrence John Stubbs. These collaborations have likely enriched his research and development efforts.

Conclusion

Nigel Paul Michael's contributions to the field of fluorescence detection and protein engineering have made a significant impact on scientific research. His innovative patents and collaborations highlight his role as a leading inventor in this area.