The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Feb. 01, 2001
Nicholas Thomas, Whitchurch, GB;
Nigel Paul Michael, Whitchurch, GB;
Valerie Millar, Whitchurch, GB;
Beth Davies, Whitchurch, GB;
Mark Samuel Jonathan Briggs, Whitchurch, GB;
Nicholas Thomas, Whitchurch, GB;
Nigel Paul Michael, Whitchurch, GB;
Valerie Millar, Whitchurch, GB;
Beth Davies, Whitchurch, GB;
Mark Samuel Jonathan Briggs, Whitchurch, GB;
GE Healthcare UK Limited, Amersham, GB;
Abstract
Disclosed is a method for increasing the fluorescence of a Cyanine dye molecule comprising at least one NOgroup characterized by the reduction of the at least one NOgroup to NHOH or NHby the action of a nitroreductase. The cyanine dye molecule comprising at least one NOgroup can be used as a substrate for detecting nitroreductase enzyme activity in a composition and allows for the use of a nitroreductase enzyme in an enzyme-reporter system for the detection of analytes, binding reactions or gene expression.