Nicholas H Putnam

Title: Innovations by Nicholas H. Putnam

Introduction

Nicholas H. Putnam is a prominent inventor based in Waltham, MA (US). He has made significant contributions to the field of genomics, holding a total of 7 patents. His work focuses on innovative methods for nucleic acid assembly and structural information recovery.

Latest Patents

One of his latest patents is titled "Tagging nucleic acids for sequence assembly." This patent discloses various approaches for generating long-distance contiguity information to facilitate contig assembly and phase determination. Nucleic acids are assembled into complexes using binding moieties, ensuring that when the nucleic acid backbones are cleaved, the ensuing fragments remain bound. Exposed ends are tagged and ligated either to one another or to tagging moieties such as oligo labels. The ligated junctions are sequenced, and the sequence information is utilized to assemble contigs into common scaffolds or to assign phase information. Various approaches to tagging the exposed ends are presented in this patent.

Another significant patent is "Recovering long-range linkage information from preserved samples." This disclosure provides methods to isolate genome or chromosome-level structural information from preserved samples. In some cases, samples preserved under conditions where long-range nucleic acid information is believed to be irreparably lost, such as FFPE samples, are treated to recover nucleic acid-protein complexes stabilized as part of the sample preservation process. The complexes are processed to recover information regarding which nucleic acids are bound to a common complex, and this information is used to recover genomic structural information.

Career Highlights

Nicholas H. Putnam is currently associated with Dovetail Genomics, LLC, where he continues to innovate in the field of genomics. His work has been instrumental in advancing the understanding of nucleic acid interactions and structural genomics.

Collaborations

He collaborates with notable colleagues such as Jonathan Stites and Brandon J. Rice, contributing to a dynamic research environment that fosters innovation.

Conclusion

Nicholas H. Putnam's contributions to genomics through his patents and collaborations highlight his role as a leading inventor in the field. His innovative approaches are paving the way for advancements in nucleic acid research and applications.