Company Filing History:
Years Active: 2015-2016
Title: The Innovative Contributions of Nicholas A. Rossi in Nucleic Acid Delivery
Introduction
Nicholas A. Rossi, based in Madison, WI, is a prominent inventor with a robust portfolio consisting of five patents. His groundbreaking work primarily focuses on developing polymers designed for the targeted delivery of nucleic acids in vivo. Rossi’s inventions have significant implications in therapeutic applications, particularly in the field of RNA interference (RNAi).
Latest Patents
Rossi's latest patents showcase his innovative approach to polymer chemistry and biological applications. Two notable inventions include:
1. **Poly(vinyl ester) polymers for in vivo nucleic acid delivery**: This invention involves membrane-active poly(vinyl ester) polymers and compositions that target RNA interference polynucleotides for cellular delivery in living organisms. The polymers are designed to conjugate with RNAi polynucleotides and are reversibly modified for efficient in vivo targeting. The membrane activity of these polymers allows the movement of RNAi polynucleotides from outside the cell into the interior, enhancing therapeutic effectiveness with physiological responsiveness.
2. **Poly(acrylate) polymers for in vivo nucleic acid delivery**: Similar to the previous invention, this patent details membrane-active poly(acrylate) polymers intended for the targeted delivery of RNAi polynucleotides. These polymers also undergo reversible modification to facilitate effective in vivo delivery. Their membrane activity allows RNAi polynucleotides to efficiently traverse cellular membranes, thereby enabling novel therapeutic avenues for gene silencing.
Career Highlights
Throughout his career, Rossi has made significant strides in the field of polymer science and biomedicine. He has made substantial contributions to the advancement of nucleic acid delivery systems, which are critical in targeted therapy and precision medicine. His work not only demonstrates technical ingenuity but also the potential to revolutionize treatment methodologies.
Collaborations
During his professional journey, Rossi has collaborated with notable experts in the field, including Darren H. Wakefield and Dan Sheik. Their combined expertise has facilitated innovative developments in RNA delivery mechanisms, enhancing the effectiveness and specificity of therapeutic agents.
Conclusion
Nicholas A. Rossi stands out as a distinguished inventor in the realm of nucleic acid delivery systems. With five patents to his name, his contributions continue to shape the landscape of biomedicine. Further developments in his polymer-based innovations hold promise for future advancements in targeted therapies, which could benefit a wide range of medical applications.