The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2016
Filed:
Jun. 22, 2015
Applicant:
Arrowhead Madison Inc., Madison, WI (US);
Inventors:
Darren H Wakefield, Fitchburg, WI (US);
Nicholas A Rossi, Madison, WI (US);
Dan Sheik, San Diego, CA (US);
Assignee:
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); C08F 218/04 (2006.01); C08F 218/10 (2006.01); C12N 15/113 (2010.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48176 (2013.01); A61K 31/7105 (2013.01); A61K 47/482 (2013.01); C08F 218/04 (2013.01); C08F 218/10 (2013.01); C12N 15/113 (2013.01); C08F 2218/22 (2013.01); C12N 2310/14 (2013.01); C12N 2310/351 (2013.01); C12N 2320/30 (2013.01);
Abstract
The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.