This inventor holds 1 USPTO granted patent. Top assignee: University of Delaware. Active years: 2012.
Company Filing History:
Years Active: 2012
Title: The Innovative Contributions of Ni Yan
Introduction
Ni Yan is a notable inventor based in Glen Mills, PA (US). He has made significant contributions to the field of bio-orthogonal chemistry, particularly through his innovative patent related to tetrazine-based coupling reagents. His work has implications for various applications in biological media.
Latest Patents
Ni Yan holds a patent for "Tetrazine-based bio-orthogonal coupling reagents and methods." This patent describes coupling reactions that are suitable for use in both organic and aqueous media. The process involves contacting a 1,2,4,5-tetrazine with a dienophile, which may be covalently bonded to a protein. The coupling reaction can be performed in biological media, including those containing cells or cell lysates. The reactions can occur in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and/or Sharpless-Huisgen reactions. Notably, novel 3-substituted cyclopropene compounds and trans-cyclooctenes serve as exemplary dienophiles for these reactions.
Career Highlights
Ni Yan is affiliated with the University of Delaware, where he continues to advance his research in bio-orthogonal chemistry. His work has garnered attention for its potential applications in various scientific fields, including biochemistry and molecular biology.
Collaborations
Ni Yan has collaborated with esteemed colleagues such as Joseph M. Fox and Melissa Blackman. These collaborations have further enriched his research and contributed to the advancement of innovative solutions in his field.
Conclusion
Ni Yan's contributions to the field of bio-orthogonal chemistry through his patent and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in scientific research and applications.