Location History:
- Cupertino, CA (US) (1994 - 1997)
- Los Altos, CA (US) (2013 - 2016)
Company Filing History:
Years Active: 1994-2016
Title: Neelima M Bhat: Innovator in Cell Membrane Research
Introduction
Neelima M Bhat is a prominent inventor based in Cupertino, CA, known for her significant contributions to the field of cell membrane research. With a total of seven patents to her name, she has made remarkable advancements in the understanding and manipulation of cell membranes, particularly in the context of therapeutic applications.
Latest Patents
Among her latest patents is the invention titled "Antibody Induced Cell Membrane Wounding." This patent describes compositions and methods for inducing cell membrane wounding, cell permeabilization, and cell killing. The composition includes a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. The preferred agent is an IgM, and the addition of a crosslinking agent enhances cell wounding and killing. Notably, at sublethal concentrations in vivo, these antibodies can permeabilize cells and significantly improve responses to chemotherapeutic agents, even in patients who are refractory to such treatments. Another significant patent is related to "CDIM Binding Proteins and Uses Thereof." This disclosure focuses on Cell Death Inducing Molecule (CDIM) binding proteins and their pharmaceutical compositions. It provides insights into selectively depleting and killing B cells, including neoplastic B cells, and encompasses methods for treating patients with B cell proliferative diseases.
Career Highlights
Neelima has worked with esteemed institutions such as Leland Stanford Junior University and IgM Biosciences, Inc. Her work has been pivotal in advancing the understanding of cell biology and therapeutic interventions.
Collaborations
Throughout her career, Neelima has collaborated with notable professionals, including Marcia M Bieber and Nelson N Teng. These collaborations have contributed to her innovative research and development efforts.
Conclusion
Neelima M Bhat's contributions to cell membrane research and her innovative patents highlight her role as a leading inventor in the field. Her work continues to pave the way for advancements in therapeutic applications and cancer treatment.