The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Feb. 08, 2013
Nelson N. H. Teng, Hillsborough, CA (US);
Neelima M. Bhat, Los Altos, CA (US);
Marcia M. Bieber, Los Altos, CA (US);
Bruce A. Keyt, Hillsborough, CA (US);
Nelson N. H. Teng, Hillsborough, CA (US);
Neelima M. Bhat, Los Altos, CA (US);
Marcia M. Bieber, Los Altos, CA (US);
Bruce A. Keyt, Hillsborough, CA (US);
IGM BIOSCIENCES, INC., Santa Clara, CA (US);
Abstract
The present disclosure relates to Cell Death Inducing Molecule ('CDIM') binding proteins and pharmaceutical compositions thereof. Particularly, the disclosure provides CDIM binding proteins that are useful in the selective depleting and killing of B cells, including neoplastic B cells as well as neoplastic cells that are not of B-cell origin that express CDIM-like antigens. In addition, the disclosure encompasses polynucleotides encoding the disclosed antigen binding proteins, and expression systems for producing the same. Further the present disclosure encompasses methods of treating patients with B cell proliferative- and mediated diseases by administering the CDIM binding proteins as well as diagnostic assays for identifying proteins that bind to CDIM. The disclosure further contemplates diagnostic assays for identifying patient populations that can be treated with the CDIM binding proteins.