Natarajan Sethuraman

Title: Natarajan Sethuraman: Innovator in Therapeutic Enzymes

Introduction

Natarajan Sethuraman is a notable inventor based in Columbia, SC (US). He has made significant contributions to the field of therapeutic enzymes, holding a total of 3 patents. His work focuses on developing innovative methods for producing enzymes that have potential applications in treating various diseases, including cancer and viral infections.

Latest Patents

One of his latest patents is a method for producing a therapeutically suitable glutaminase. This invention involves the molecular cloning of DNA encoding a glutaminase that is free of contaminating endotoxin. The resulting polypeptide has been identified as a potent anti-viral agent and, when coupled with an anti-tumor monoclonal antibody, serves as a powerful anticancer agent. This glutaminase is particularly effective in treating lung, breast, and colon cancer cells, as well as HIV-infected cells.

Another significant patent by Sethuraman is related to the cloning, overexpression, and therapeutic use of bioactive histidine ammonia lyase (HAL). This enzyme, isolated from Corynebacteriaceae, can decrease serum histidine levels and induce the accumulation of urocanic acid. It is uniquely suitable for combination therapy with L-histidinol to treat histidine- and/or histamine-dependent pathologies, including infectious viruses like Respiratory Syncytial Virus (RSV), Herpes Simplex Virus (HSV), and Human Immunodeficiency Virus (HIV), as well as various cancers.

Career Highlights

Throughout his career, Natarajan Sethuraman has worked with several organizations, including Me Medical Enzymes AG and the University of South Carolina. His research and innovations have significantly advanced the understanding and application of therapeutic enzymes in medicine.

Collaborations

Sethuraman has collaborated with notable individuals in his field, including Joseph W. Roberts and Thomas W. MacAllister. These collaborations have contributed to the development and refinement of his patented technologies.

Conclusion

Natarajan Sethuraman is a distinguished inventor whose work in therapeutic enzymes has the potential to revolutionize treatments for cancer and viral infections. His innovative patents reflect his commitment to advancing medical science and improving patient outcomes.