This inventor holds 2 USPTO granted patents. Top assignee: Ramot University Authority for Applied Research and Industrial Development Limited. Active years: 2003-2005.
Company Filing History:
Years Active: 2003-2005
Title: Naomi Dafni: Innovator in Genetic Screening Methods
Introduction
Naomi Dafni is a prominent inventor based in Caesarea, Israel. She has made significant contributions to the field of genetic screening, holding 2 patents that focus on innovative methods for identifying synthetic lethal properties in genes.
Latest Patents
Her latest patents include groundbreaking methods for genetic screening. One patent describes a method for screening molecules that exhibit synthetic lethal properties when combined with a gene of interest carrying a non-lethal mutation. This method involves transfecting a first reporter gene into mammalian cells, selecting clones that stably express the reporter gene, and introducing a survival plasmid that contains a functioning copy of the gene of interest. The process culminates in identifying molecules that impose selective pressure, thereby revealing their synthetic lethal properties.
Another patent outlines a screening method that applies the principle of synthetic lethality to a gene of interest in non-yeast eukaryotic cells. This method can be utilized to screen chemical libraries or DNA molecules to identify modulators of gene function that are synergistically lethal when combined with an incapacitated gene of interest. The patent also describes episomal survival plasmids and kits that can be used in conjunction with the screening method.
Career Highlights
Naomi Dafni is affiliated with Ramot University Authority for Applied Research and Industrial Development Limited, where she continues to advance her research in genetic screening. Her work has garnered attention for its potential applications in therapeutic development and personalized medicine.
Collaborations
Throughout her career, Naomi has collaborated with notable colleagues, including Dan Canaani and Arnold Simons. These partnerships have contributed to the advancement of her research and the successful development of her patented methods.
Conclusion
Naomi Dafni is a trailblazer in the field of genetic screening, with her innovative methods paving the way for future research and applications. Her contributions are significant in the ongoing quest to understand genetic interactions and their implications in health and disease.