The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2003
Filed:
Sep. 08, 1999
Applicant:
Inventors:
Dan Canaani, Ra'Anana, IL;
Yoram Oron, Tel Aviv, IL;
Arnold Simons, Carcur, IL;
Naomi Dafni, Keisaria, IL;
Iris Dotan, Tel Aviv, IL;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 ; C12N 1/574 ; C07H 2/102 ;
U.S. Cl.
CPC ...
C12Q 1/68 ; C12N 1/574 ; C07H 2/102 ;
Abstract
A screening method which applies the principle of synthetic lethality to a gene of interest in non-yeast eukaryotic cells. The method may be used to screen either a chemical library in order to identify a molecule having a gene-specific lethal property in the cells, or to screen a group of DNA molecules in order to identify among them one or more modulators of gene function which are synergistically lethal to the cells together with an incapacitated gene of interest. Also described are episomal survival plasmids and kits which may be used with the method.