Company Filing History:
Years Active: 1998-2001
Title: Myrna E Trumbauer: Innovator in Transgenic Research
Introduction
Myrna E Trumbauer is a prominent inventor based in Yardley, PA (US). She has made significant contributions to the field of biotechnology, particularly in the development of transgenic models for studying human diseases. With a total of 3 patents, her work has advanced our understanding of amyloid precursor proteins and their role in neurodegenerative conditions.
Latest Patents
Among her latest patents is the invention of a transgenic mouse expressing a familial form of human amyloid precursor protein. This innovative model allows for the examination of compounds that can modulate the production of human amyloid precursor protein in the brain and isolated neuronal cells. Specifically, her work exemplifies transgenic mice whose genome includes a DNA sequence encoding a human amyloid precursor protein FAD variant, where at amino acid position 717, valine is substituted by isoleucine. These mice have been shown to produce the APP-FAD variant in their brains, as confirmed by mRNA and protein assays. Another notable patent involves the expression of human interleukin-1.beta. in a transgenic animal, further showcasing her expertise in genetic engineering.
Career Highlights
Myrna E Trumbauer is currently associated with Merck & Company, Inc., where she continues to push the boundaries of scientific research. Her work has not only contributed to the understanding of amyloid precursor proteins but has also paved the way for potential therapeutic interventions in neurodegenerative diseases.
Collaborations
Throughout her career, Myrna has collaborated with esteemed colleagues, including Howard Y Chen and Hui Zheng. These partnerships have enhanced her research and expanded the impact of her inventions in the scientific community.
Conclusion
Myrna E Trumbauer's innovative work in transgenic research has made her a key figure in the biotechnology field. Her patents and collaborations reflect her commitment to advancing scientific knowledge and improving health outcomes.
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