The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2001
Filed:
Apr. 28, 1997
Gurparlash Singh, Bedminster, NJ (US);
Howard Y. Chen, Westfield, NJ (US);
Robert P. Heavens, Harlow, GB;
Dalip J. S. Sirinathsinghji, Harlow, GB;
David W. Smith, Harlow, GB;
Myrna E. Trumbauer, Yardley, PA (US);
Leonardus H. T. Van Der Ploeg, Scotch Plains, NJ (US);
Aurawan Vongs, Sewell, NJ (US);
Hui Zheng, Edison, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
Transgenic non-human mammals which express in their brains a nucleic acid construct comprising a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine. These transgenic non-human mammals can be assays systems for determining compounds which are effective in modulating production of human amyloid precursor protein in brain and in isolated neuronal cells. Specifically exemplified are transgenic mice whose genome comprises a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine operably linked to a Thy-1 promoter. The mice are shown to produce the APP-FAD variant in their brains by mRNA and protein assays.