Mitsuru Nonogawa

Title: Mitsuru Nonogawa: Innovator in Nucleic Acid Synthesis

Introduction

Mitsuru Nonogawa is a prominent inventor based in Osaka, Japan. He has made significant contributions to the field of nucleic acid synthesis, holding 2 patents that showcase his innovative methods.

Latest Patents

One of his latest patents is a method for liquid-phase synthesis of nucleic acid. In this method, an oligonucleotide represented by formula (II) is prepared using a novel nucleoside monomer compound represented by formula (I). The novel nucleoside monomer compound is a nucleoside, where the base moiety is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group that has at least one hydrophobic group. This method eliminates the need for column-chromatographic purification in every reaction and allows for base elongation in both the 3′- and 5′-directions, achieving efficient liquid-phase mass synthesis of oligonucleotides.

Another patent by Nonogawa also focuses on a method for liquid-phase synthesis of nucleic acid. Similar to the previous patent, it utilizes a novel nucleoside monomer compound represented by formula (I). The method again dispenses with column-chromatographic purification in every reaction and enables base elongation in both directions, facilitating efficient synthesis.

Career Highlights

Mitsuru Nonogawa has worked with notable companies, including Takeda Pharmaceutical Company Limited. His work in these organizations has contributed to advancements in pharmaceutical research and development.

Collaborations

Throughout his career, Nonogawa has collaborated with esteemed colleagues such as Toshiaki Nagata and Hideki Saito. These collaborations have further enriched his research and innovations in nucleic acid synthesis.

Conclusion

Mitsuru Nonogawa is a distinguished inventor whose work in nucleic acid synthesis has led to significant advancements in the field. His innovative methods and collaborations continue to influence research and development in pharmaceuticals.