The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2019
Filed:
Nov. 13, 2013
Takeda Pharmaceutical Company Limited, Osaka-shi, Osaka, JP;
Mitsuru Nonogawa, Osaka, JP;
Toshiaki Nagata, Osaka, JP;
Hideki Saito, Osaka, JP;
Tsuneo Yasuma, Osaka, JP;
TAKEDA PHARMACEUTICAL COMPANY LIMITJED, Osaka, JP;
Abstract
In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R, Y, Base, Z, Ar, R, Rand n are each as defined in Claim]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method cars dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3'-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.