Mireille Hogue

Title: Mireille Hogue: Innovator in Biosensor Technology

Introduction

Mireille Hogue is a distinguished inventor based in Laval, Canada, renowned for her ground-breaking contributions to the field of biosensor technology. With two patents to her name, Hogue has focused on developing innovative biosensors that enhance our ability to monitor biological processes and understand cellular interactions.

Latest Patents

Hogue's latest patents showcase her expertise in creating advanced biosensing technologies. The first patent describes a biosensor based on Gβγ-interacting proteins to monitor G-protein activation. This invention utilizes resonance energy transfer (RET) and protein-fragment complement assays (PCA) to assess G-protein activity. It focuses on the dynamic competition between the Gα subunit and a Gβγ-interacting protein for binding to the Gβγ dimer, thus enabling detailed monitoring of G-protein preferences and activation profiles.

The second patent introduces Renilla-based biosensors geared toward tracking biomolecule localization and trafficking within cells. These bioluminescence resonance energy transfer (BRET) biosensors allow for the robust monitoring of protein trafficking and cellular compartmentalization. They use a GFP/Luc BRET pair, providing high sensitivity suited for high-throughput screening applications. This patent opens avenues for assessing protein endocytosis, recycling, and maturation, as well as understanding biomolecule dynamics in cellular processes.

Career Highlights

Mireille Hogue has made significant strides in her career, contributing invaluable research at notable establishments, including the Université de Montréal and the Royal Institution for the Advancement of Learning at McGill University. Her work encapsulates a blend of innovative research and practical applications in biosensor technology, placing her at the forefront of her field.

Collaborations

Throughout her career, Hogue has collaborated with esteemed colleagues, including Michel Bouvier and Christian Le Gouill. These collaborations have enriched her research, allowing for the exchange of ideas and advancements in biosensor technologies. Working alongside such talented individuals has been a vital aspect of her success as an inventor.

Conclusion

Mireille Hogue's contributions to biosensor technology significantly impact fields such as pharmacology and cellular biology. Her innovative patents reflect a commitment to advancing scientific knowledge and understanding of complex biological systems. With ongoing research and collaborations, Hogue continues to inspire future innovations in the world of biosensing.