Company Filing History:
Years Active: 2006-2009
Title: Minoru Yamaguchi: Innovator in Protein Modification
Introduction
Minoru Yamaguchi is a distinguished inventor based in Kyoto, Japan. He has made significant contributions to the field of protein and peptide modification, holding a total of 3 patents. His innovative methods have advanced the understanding and application of protein chemistry.
Latest Patents
Yamaguchi's latest patents include groundbreaking techniques for modifying proteins and peptides. One notable invention is a method for derivatizing proteins or peptides with sulfonic acid groups. This method effectively introduces sulfonic acid groups into the N-terminus of a protein or peptide through a modification step involving a disulfide compound, followed by a cleavage step to convert the disulfide bond into a sulfonic acid group. Additionally, he has developed a method for analyzing proteins or peptides using mass spectrometry, which simplifies the process of derivatization.
Another significant patent focuses on a simple and cost-effective method for selectively modifying the C-terminal of proteins or peptides. This method involves forming an intramolecular oxazolone ring at the C-terminal, followed by a ring-opening reaction to produce a modified protein or peptide. The versatility of this method allows for various modifications using nucleophilic compounds or active esterifying agents.
Career Highlights
Minoru Yamaguchi is currently associated with Shimadzu Corporation, where he continues to innovate in the field of protein chemistry. His work has not only contributed to academic research but has also had practical applications in various industries.
Collaborations
Throughout his career, Yamaguchi has collaborated with notable colleagues, including Shigemi Norioka and Norikazu Ueyama. These collaborations have further enriched his research and development efforts.
Conclusion
Minoru Yamaguchi's contributions to protein and peptide modification are invaluable. His innovative patents and ongoing work at Shimadzu Corporation highlight his role as a leading inventor in the field. His advancements continue to influence both research and practical applications in biochemistry.