The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2009
Filed:
Oct. 13, 2004
Shigemi Norioka, Ibaraki, JP;
Minoru Yamaguchi, Kyoto, JP;
Hiroki Kuyama, Kyoto, JP;
Takashi Obama, Kyoto, JP;
Eiji Ando, Kyoto, JP;
Takashi Nakazawa, Nara, JP;
Norikazu Ueyama, Osaka, JP;
Taka-aki Okamura, Osaka, JP;
Shigemi Norioka, Ibaraki, JP;
Minoru Yamaguchi, Kyoto, JP;
Hiroki Kuyama, Kyoto, JP;
Takashi Obama, Kyoto, JP;
Eiji Ando, Kyoto, JP;
Takashi Nakazawa, Nara, JP;
Norikazu Ueyama, Osaka, JP;
Taka-aki Okamura, Osaka, JP;
Shimadzu Corporation, Kyoto, JP;
Abstract
The present invention provides a method for effectively introducing sulfonic acid groups into the N-terminus of a protein or a peptide. The method comprises a modification step to react a N-terminus in a protein or peptide with a compound A which includes disulfide group and a cleavage step to cleave a disulfide bond of the disulfide group to convert into a sulfonic acid group. The present invention also provides a method of analyzing proteins or peptides easily and effectively on mass spectrometry and an intermediate that can be used to effectively derivatize proteins or peptides as sulfonic acid derivatives.