Company Filing History:
6 out of 3,497 
1 out of 1,786 Years Active: 1989-2011
Title: Hiroki Kuyama: Innovator in Phosphopeptide Analysis
Introduction
Hiroki Kuyama is a distinguished inventor based in Kyoto, Japan. He has made significant contributions to the field of peptide analysis, holding a total of 6 patents. His innovative methods have advanced the understanding and detection of phosphopeptides, which are crucial in various biological processes.
Latest Patents
One of Kuyama's latest patents is a phosphopeptide analysis method. This invention utilizes a matrix reagent prepared by adding methylenediphosphonic acid (MDPNA) to a matrix of 2,5-dihydroxybenzoic acid (DHBA). This combination allows for a higher peak intensity of phosphopeptides compared to samples using DHBA alone or with phosphoric acid as an additive. Additionally, this method enables the detection of peptides that are otherwise undetectable with traditional methods.
Another notable patent involves methods for derivatizing proteins or peptides with sulfonic acid groups. This innovative approach effectively introduces sulfonic acid groups into the N-terminus of proteins or peptides. The method includes a modification step that reacts the N-terminus with a compound containing a disulfide group, followed by a cleavage step to convert the disulfide bond into a sulfonic acid group. This invention also simplifies the analysis of proteins or peptides using mass spectrometry.
Career Highlights
Kuyama has worked with prominent companies such as Shimadzu Corporation and Mitsui Chemicals, Inc. His experience in these organizations has contributed to his expertise in the field of peptide analysis and innovation.
Collaborations
Throughout his career, Kuyama has collaborated with notable colleagues, including Shigemi Norioka and Minoru Yamaguchi. These partnerships have fostered a collaborative environment that has led to significant advancements in their respective fields.
Conclusion
Hiroki Kuyama's contributions to the field of peptide analysis through his innovative patents have made a lasting impact. His work continues to influence research and applications in biochemistry and related disciplines.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.