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Years Active: 2013-2020
Title: Innovations of Michelle Dohm in Lung Surfactant Research
Introduction
Michelle Dohm is an accomplished inventor based in Palos Park, IL (US). She has made significant contributions to the field of lung surfactant research, holding a total of 4 patents. Her work focuses on developing innovative materials that mimic natural lung surfactant proteins, which are essential for normal respiration.
Latest Patents
One of her latest patents involves nylon-3 co-polymers and synthetic lung surfactant compositions. These non-natural oligomers have shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C). The traditional methods of generating non-natural mimics of SP-B and SP-C have been limited to step-by-step, sequence-specific synthesis. This results in discrete oligomers designed to exhibit specific structural attributes. Dohm presents an alternative approach based on sequence-random copolymers containing cationic and lipophilic subunits. These nylon-3 family materials are prepared through ring-opening polymerization of β-lactams. The most effective nylon-3 polymers demonstrate promising in vitro surfactant activities in mixed lipid films. Data from pulsating bubble surfactometry indicate that films with the most surface-active polymers achieve adsorptive and dynamic-cycling properties that exceed those of discrete peptides intended to mimic SP-B. Furthermore, the attachment of an N-terminal octadecanoyl unit to the nylon-3 copolymers enhances performance by reducing the percent surface area compression needed to reach low minimum surface tension.
Career Highlights
Throughout her career, Michelle Dohm has worked with notable institutions, including Northwestern University and the Wisconsin Alumni Research Foundation. Her research has significantly advanced the understanding and development of synthetic lung surfactants.
Collaborations
Dohm has collaborated with esteemed colleagues such as Annelise E Barron and Samuel Helmer Gellman, contributing to the innovative research in her field.
Conclusion
Michelle Dohm's work in developing nylon-3 co-polymers and synthetic lung surfactants represents a significant advancement in respiratory health. Her innovative approach and collaborations continue to pave the way for future research and applications in this critical area.