Location History:
- Seattle, WA (US) (2006)
- San Francisco, CA (US) (2007)
Company Filing History:
Years Active: 2006-2007
Title: Michael Ziman: Innovator in RNA Amplification and Metabolic Pathway Research
Introduction
Michael Ziman is a notable inventor based in San Francisco, CA. He has made significant contributions to the field of molecular biology, particularly in the areas of RNA amplification and metabolic pathway research. With a total of 2 patents, Ziman's work has the potential to impact various scientific and therapeutic applications.
Latest Patents
Ziman's latest patents include a method for linearly amplifying RNA using a random-primed reverse transcriptase-in vitro transcription method. This innovative approach allows for the conversion of source RNA, preferably mRNA, into double-stranded cDNA using two random primers. One of these primers contains a RNA polymerase promoter sequence, which facilitates the transcription of the double-stranded cDNA into RNA. This method produces linearly amplified RNA with minimal 3' bias in the sequences of the amplified nucleic acid population.
Another significant patent involves methods for identifying genes indicative of activation in specific biochemical or metabolic pathways. This invention provides a framework for partially characterizing genes of unknown function by associating their expression with biological pathways. The methods also aim to identify desirable therapeutic targets within these pathways, enhancing the understanding of gene functions and their potential applications in medicine.
Career Highlights
Michael Ziman is currently employed at Rosetta Inpharmatics, Inc., where he continues to advance his research in molecular biology. His work has garnered attention for its innovative approaches and potential applications in therapeutic development.
Collaborations
Ziman collaborates with esteemed colleagues, including Colleen P Davis and Matthew N Ashby, who contribute to his research endeavors and enhance the collaborative spirit within the scientific community.
Conclusion
Michael Ziman's contributions to RNA amplification and metabolic pathway research exemplify the innovative spirit of modern science. His patents reflect a commitment to advancing molecular biology and its applications in therapeutic contexts.