Company Filing History:
Years Active: 2001-2002
Title: Michael Zachariou: Innovator in Cell Culture Technology
Introduction
Michael Zachariou is a notable inventor based in Walnut Creek, CA (US). He has made significant contributions to the field of cell culture technology, holding 2 patents that focus on innovative methods and mediums for culturing mammalian cells.
Latest Patents
Zachariou's latest patents include a "Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration." This patent discloses a cell culture medium that contains less than about 1 g/L added sodium bicarbonate, along with an organic buffer and a metal complexing agent. The medium is designed to be essentially free of added sodium bicarbonate, making it particularly useful for culturing mammalian cells engineered to produce recombinant factor VIII.
Another significant patent is the "Method for evaluating target protein quality from fermenter." This innovation utilizes a chemiluminescence-based gel assay as an indicator of fermenter health. The assay can be performed using a sample of fermentation medium directly from the fermenter, eliminating the need for complicated purification processes. The results from this assay can be correlated with the final product purification yield, serving as a predictor of purification yield before the actual purification process is conducted.
Career Highlights
Michael Zachariou is currently employed at Bayer Corporation, where he continues to advance his research and development efforts in the biotechnology sector. His work has been instrumental in improving the efficiency and effectiveness of cell culture processes.
Collaborations
Zachariou collaborates with esteemed colleagues, including Charles V Olson and Ricaredo Matanguihan, to further enhance the impact of his innovations in the field.
Conclusion
Michael Zachariou's contributions to cell culture technology through his patents and work at Bayer Corporation highlight his role as a key innovator in the biotechnology industry. His advancements are paving the way for more efficient methods in protein production and cell culture practices.