Company Filing History:
Years Active: 2003-2015
Title: Michael W. Smith: Innovator in Genetic Research
Introduction
Michael W. Smith is a notable inventor based in Jefferson, MD (US). He has made significant contributions to the field of genetic research, particularly in relation to renal disease and HIV. With a total of 2 patents, his work has the potential to impact many lives.
Latest Patents
One of his latest patents focuses on single nucleotide polymorphisms associated with renal disease. This invention provides methods for determining the genetic predisposition of individuals to develop renal diseases, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease. The methods utilize the detection of haplotype blocks comprising tag single nucleotide polymorphisms (SNPs) in a non-coding region of the MYH9 gene. Additionally, an array for detecting genetic predisposition to renal disease using probes complementary to the tag SNPs is disclosed.
Another significant patent relates to the delayed progression to AIDS by a missense allele of the CCR2 gene. This invention identifies a CCR2 deletion mutant, designated “CCR2-64I,” which has been found to correlate with a postponement of AIDS outcomes. Individuals with the CCR2-64I allele are at a reduced risk for progression from HIV-1 infection to clinical AIDS and death. The patent also includes diagnostic methods for analyzing the allelic frequency of CCR2 wild-type and 64I genes, as well as potential anti-HIV agents.
Career Highlights
Michael W. Smith works for the United States of America, as represented by the Secretary, Department of Health and Human Services. His role in this esteemed organization allows him to contribute to vital research that can lead to advancements in public health.
Collaborations
Throughout his career, Michael has collaborated with notable colleagues, including Cheryl Winkler and George E. Nelson. These partnerships have likely enhanced the scope and impact of his research.
Conclusion
Michael W. Smith is a distinguished inventor whose work in genetic research has the potential to transform the understanding and treatment of renal disease and HIV. His innovative patents reflect a commitment to advancing medical science and improving patient outcomes.