Company Filing History:
Years Active: 1984-1985
Title: Michael W. Konrad: Innovator in Bacterial Production of Polypeptides
Introduction
Michael W. Konrad is a notable inventor based in Alameda, CA (US). He has made significant contributions to the field of biotechnology, particularly in the production of heterologous polypeptides. With a total of 2 patents, his work has implications for various applications in medicine and research.
Latest Patents
Konrad's latest patents focus on innovative processes for the bacterial production of heterologous polypeptides. One of his patents describes a method for producing polypeptides, such as human IFN-.beta., that inhibit bacterial growth. This process involves transforming bacteria to express the polypeptide under the control of a trp promoter-operator. The bacteria are cultivated in a medium with a preferred carbon source, allowing for controlled expression of the polypeptide at elevated cellular densities.
Another patent outlines a process for recovering human IFN-.beta. from transformed microorganisms. This method includes disrupting bacterial cell membranes, solubilizing the IFN-.beta. into an aqueous medium, and extracting it using specific solvents while maintaining phase separation. The final step involves isolating the IFN-.beta. by precipitating it from the aqueous buffer mixture.
Career Highlights
Michael W. Konrad has been associated with Cetus Corporation, where he has furthered his research and development efforts. His work has contributed to advancements in biotechnology and has positioned him as a key figure in his field.
Collaborations
Throughout his career, Konrad has collaborated with notable colleagues, including Leo S. Lin and David F. Mark. These collaborations have enhanced the scope and impact of his research.
Conclusion
Michael W. Konrad's innovative work in the field of biotechnology, particularly in the production and recovery of heterologous polypeptides, showcases his significant contributions to science. His patents reflect a commitment to advancing medical and research applications through innovative processes.
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