Company Filing History:
Years Active: 1988-1994
Title: The Innovative Contributions of Michael T. Doel
Introduction
Michael T. Doel, an accomplished inventor based in Studley Green, Great Britain, has made significant strides in the field of biotechnology. With two notable patents to his name, his innovations reflect a commitment to advancing medical science and improving therapeutic applications.
Latest Patents
Doel's latest patents include a groundbreaking process for the recovery of recombinantly produced chymosin. This invention details a method wherein an insoluble form of chymosin precursor is generated by a bacterial host cell transformed with a specific vector. The innovative aspect of this process lies in the solubilization of the precursor, which employs high concentrations of urea or guanidine hydrochloride, along with alkaline aqueous solutions to facilitate the transformation into functional chymosin.
Additionally, Doel has developed a synthetic urogastrone gene, which codes for the expression of urogastrone or its sub-units. This invention highlights the assembly and ligation of several nucleotide blocks resulting in plasmid recombinants and transformed cells. The expression of urogastrone, a polypeptide hormone beneficial in treating ulcers and promoting wound healing, underscores the commercial viability of his invention.
Career Highlights
Throughout his career, Michael T. Doel has worked with prestigious organizations such as Celltech Limited and G.D. Searle & Company. His experience in these companies reflects a robust background in pharmaceuticals and biotechnology, paving the way for his inventive contributions.
Collaborations
Doel has collaborated with several respected individuals in the field, including Norman H. Carey and Timothy J. Harris. These partnerships have undoubtedly enriched his work and led to the development of innovative solutions in biotechnology.
Conclusion
Michael T. Doel's contributions to science through his patents demonstrate a significant commitment to innovation in biotechnology. His work not only showcases his inventive prowess but also highlights the impact of collaboration and experience in driving advancements in medical applications. As research continues to evolve, Doel's innovations lay the groundwork for future breakthroughs in therapeutic production and application.