Michael Robert Shortreed

Title: Michael Robert Shortreed: Innovator in Biomolecular Analysis

Introduction

Michael Robert Shortreed is a distinguished inventor based in Portage, WI (US). He has made significant contributions to the field of biomolecular analysis, holding a total of 5 patents. His work focuses on innovative technologies that enhance the understanding of biomolecular interactions.

Latest Patents

Shortreed's latest patents include groundbreaking advancements such as "Surface plasmon resonance compatible carbon thin films." This technology provides SPR-compatible substrates for high-density microarray fabrication and analyses. The novel carbon-on-metal thin film substrate architecture allows for the integration of surface plasmon resonance detection with photolithographically fabricated biomolecule arrays. This integration is crucial for analyzing specific DNA-DNA, DNA-RNA, and DNA-protein binding interactions. Additionally, these new substrates can determine the secondary structure of RNA molecules and probe the sequence-specific binding kinetics and affinity of proteins and small molecules. They also serve as substrates for small-molecule combinatorial chemistry platforms, which are essential for drug discovery applications.

Another notable patent is the "Integrated electrospray ionization emitter and detection cell for parallel measurements by fluorescence and mass spectrometry." This invention combines a mass spectrometer electrospray emitter with a fluorescence detector, improving volumetric measurements of separate components from a liquid chromatography column. It enhances the correlation between the readings of these instruments while reducing dead volume and sample size requirements.

Career Highlights

Throughout his career, Shortreed has worked with prominent organizations such as the Wisconsin Alumni Research Foundation and the University of Illinois. His innovative work has positioned him as a key figure in the field of biomolecular research.

Collaborations

Shortreed has collaborated with notable colleagues, including Lloyd M. Smith and Joshua J. Coon. These partnerships have further advanced his research and contributed to the development of his patented technologies.

Conclusion

Michael Robert Shortreed's contributions to biomolecular analysis through his patents and collaborations highlight his role as an influential inventor. His work continues to impact the field significantly, paving the way for future innovations in drug discovery and biomolecular research.