The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2017
Filed:
Feb. 26, 2008
Lloyd M. Smith, Madison, WI (US);
Matthew R. Lockett, Madison, WI (US);
Michael R. Shortreed, Portage, WI (US);
Robert M. Corn, Corona del Mar, CA (US);
Stephen Weibel, Madison, WI (US);
Robert J. Hamers, Madison, WI (US);
Bin Sun, Falls Church, VA (US);
Lloyd M. Smith, Madison, WI (US);
Matthew R. Lockett, Madison, WI (US);
Michael R. Shortreed, Portage, WI (US);
Robert M. Corn, Corona del Mar, CA (US);
Stephen Weibel, Madison, WI (US);
Robert J. Hamers, Madison, WI (US);
Bin Sun, Falls Church, VA (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
SPR-compatible substrates for high density microarray fabrication and analyses are provided. Novel carbon-on-metal thin film substrate architecture permits the integration of surface plasmon resonance detection with photolithographically fabricated biomolecule arrays for the analysis of biomolecular interactions. The utility of the technology is shown in the analysis of specific DNA-DNA, DNA-RNA and DNA-protein binding interactions. These new substrates may be used to determine the secondary structure of RNA molecules, to probe the sequence-specific binding kinetics and affinity of proteins and small molecules, and as substrates for small-molecule combinatorial chemistry platforms for drug discovery applications.