Location History:
- Harleyville, PA (US) (2006)
- Harleysville, PA (US) (2007)
Company Filing History:
1 out of 2,079 
1 out of 363 
Years Active: 2006-2007
Title: Michael Renzi: Innovator in Neuroprotective Therapies
Introduction
Michael Renzi is a notable inventor based in Harleysville, PA (US), recognized for his contributions to the field of neuroprotective therapies. With a total of two patents to his name, Renzi has made significant strides in developing methods for treating diseases of the nervous system.
Latest Patents
Renzi's latest patents include innovative approaches to neuroprotection. One of his patents focuses on neuroprotective peptides, detailing methods of treating diseases of the nervous system through the administration of compositions that possess the neurological therapeutic activity of human erythropoietin. These compositions encompass therapeutic agents such as peptides, peptide dimers, polypeptides, and proteins that exhibit the full range of biological activity of human erythropoietin or specific biological activities. Additionally, improved therapeutic regimens are provided, where erythropoietin is administered at concentrations below those typically required to stimulate hematopoiesis.
Another significant patent addresses methods for SHP1 mediated neuroprotection. This research analyzes the effect of erythropoietin (EPO) on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1. The findings indicate that EPO can decrease the expression of its negative regulator SHP-1, with this decrease being dose-dependent and lasting up to 24 hours post-treatment. Assays have been developed to identify compounds that can effectively regulate SHP1 activity in neural cells.
Career Highlights
Throughout his career, Michael Renzi has worked with prominent companies in the pharmaceutical industry, including Janssen Pharmaceutica and Ortho-McNeil Pharmaceutical Corporation. His work in these organizations has contributed to advancements in therapeutic strategies for neurological conditions.
Collaborations
Renzi has collaborated with notable colleagues, including Linda K. Jolliffe and Francis Farrell, enhancing the impact of his research through teamwork and shared expertise.
Conclusion
Michael Renzi's innovative work in neuroprotective therapies showcases his commitment to advancing medical science. His patents reflect a deep understanding of the complexities of the nervous system and offer promising avenues for treatment.