The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2006
Filed:
Mar. 11, 2003
Michael Renzi, Harleyville, PA (US);
Navneeth Thirumalai, Kendall Park, NJ (US);
Linda Jolliffe, Hillsborough, NJ (US);
Francis X. Farrell, Doylestown, PA (US);
Michael Renzi, Harleyville, PA (US);
Navneeth Thirumalai, Kendall Park, NJ (US);
Linda Jolliffe, Hillsborough, NJ (US);
Francis X. Farrell, Doylestown, PA (US);
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells.