This inventor holds 1 USPTO granted patent. Top assignees: Cornell University, University of California. Active years: 2016.
Company Filing History:
1 out of 2,948 
1 out of 15,977 
Years Active: 2016
Title: Michael R Wasserman: Innovator in Antibiotic Drug Discovery
Introduction
Michael R Wasserman is a notable inventor based in New York, NY (US). He has made significant contributions to the field of antibiotic drug discovery, particularly through his innovative approaches to understanding ribosomal function. His work has implications for the development of new antibiotics, which are crucial in combating antibiotic resistance.
Latest Patents
Wasserman holds a patent titled "Ribosomal targets for antibiotic drug discovery." This invention relates to methods for identifying molecules that bind in the neomycin binding pocket of a bacterial ribosome. The patent details how the ribosome binds tRNA in two distinct functional states, as determined by x-ray crystallography. One state positions tRNA in the peptidyl-tRNA binding site, while the second, a fully rotated state, is stabilized by ribosome recycling factor (RRF) and binds tRNA in a highly bent conformation in a hybrid peptidyl/exit (P/E) site. Additionally, the invention includes various assays, such as a single-molecule assay for ribosome recycling, and methods to identify compounds that interfere with ribosomal function by detecting newly identified intermediate FRET states using known and novel FRET pairs on the ribosome. The invention also provides vectors and compositions with an N-terminally tagged S13 protein.
Career Highlights
Wasserman has worked at prestigious institutions, including Cornell University and the University of California. His research has focused on the intricate mechanisms of ribosomal function and its implications for antibiotic development. His innovative approaches have positioned him as a key figure in the field of drug discovery.
Collaborations
Wasserman has collaborated with notable colleagues, including Michael Brian Feldman and Leyi Wang. These collaborations have further enriched his research and contributed to advancements in understanding ribosomal mechanisms.
Conclusion
Michael R Wasserman's contributions to antibiotic drug discovery through his innovative patent and research collaborations highlight his importance in the scientific community. His work continues to pave the way for new approaches in combating antibiotic resistance.