Michael Paolo Bastner Sandrini

Title: Michael Paolo Bastner Sandrini: Innovator in Obesity Treatment

Introduction

Michael Paolo Bastner Sandrini is a notable inventor based in Bagsvaerd, Denmark. He has made significant contributions to the field of obesity treatment through his innovative patents. With a total of two patents to his name, Sandrini is recognized for his work in developing compounds that target the brain's regulation of body weight.

Latest Patents

One of Sandrini's latest patents focuses on compounds for the treatment of obesity. This invention involves a construct that targets areas in the brain responsible for body weight regulation, utilizing an allosteric ligand to a receptor located in the blood-brain barrier (BBB). The preferred compounds for regulating body weight include GLP-1 receptor agonists (GLP-1RA), and the invention highlights the transferrin receptor (TfR) as a key receptor in the BBB. In vivo studies in mice have demonstrated that the active construct leads to a significant reduction in food intake and weight loss compared to inactive controls.

Another patent by Sandrini pertains to MIC-1 fusion proteins. This invention includes compounds that consist of fusion proteins with a MIC-1 protein or an analog at the C-terminus and a functional variant of human serum albumin at the N-terminus, connected via a peptide linker. These compounds exhibit MIC-1 activity and are associated with pharmaceutical compositions that include acceptable excipients, as well as their medical uses.

Career Highlights

Michael Paolo Bastner Sandrini is currently employed at Novo Nordisk A/S, a leading global healthcare company. His work at Novo Nordisk focuses on innovative solutions for chronic diseases, particularly obesity. Sandrini's research and inventions have the potential to significantly impact the treatment landscape for obesity and related conditions.

Collaborations

Sandrini collaborates with esteemed colleagues, including Allan Christian Shaw and Charlotte Helgstrand. Their combined expertise contributes to the advancement of research and development in the field of obesity treatment.

Conclusion

Michael Paolo Bastner Sandrini is a prominent inventor whose work in obesity treatment is paving the way for innovative therapeutic solutions. His patents reflect a deep understanding of the complexities of body weight regulation and offer promising avenues for future research and application.