The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Jun. 20, 2019
Novo Nordisk A/s, Bagsvaerd, DK;
Nikolaj Kulahin Roed, Birkeroed, DK;
Michael Paolo Bastner Sandrini, Alleroed, DK;
Jesper Lau, Farum, DK;
Paw Bloch, Jyllinge, DK;
Anna Secher, Koebenhavn NV, DK;
Adam Paul Chambers, Alleroed, DK;
Jim McGuire, Berkeley, CA (US);
Lotte Bjerre Knudsen, Jerslev, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The invention relates to a construct comprising a compound targeting areas in the brain involved in the regulation of body weight and an allosteric ligand to a receptor located in the blood-brain barrier (BBB). The invention also relates to compositions and uses of such construct, for example in the prevention or treatment of overweight and obesity. Preferred compounds for regulation of body weight include GLP-1 receptor agonists (GLP-1RA), and preferred receptors located in the BBB include the transferrin receptor (TfR). Exemplary fusions and conjugates of GLP-1 RA's and anti TfR-Fab's exhibit an increased binding to brain regions expressing the GLP-1 receptor as compared to fusions or conjugates with inactive control Fab's, in particular in brain areas protected by the BBB. In vivo mice studies confirm increased reduction in food intake as well as weight loss for the active construct compared to the inactive one.