Michael Kalafatis

Title: The Innovations of Michael Kalafatis

Introduction

Michael Kalafatis is a notable inventor based in Shaker Heights, Ohio. He has made significant contributions to the field of biotechnology, particularly in the area of coagulation and apoptosis. With a total of eight patents to his name, Kalafatis has demonstrated a commitment to advancing medical science through innovative solutions.

Latest Patents

Among his latest patents is the development of recombinant prothrombin analogues and their uses. This invention focuses on the activation of prothrombin to α-thrombin during the coagulation process. Key residues in the structure of prothrombin allow for modulation of its activation, and certain embodiments provide a recombinant prothrombin with at least one point mutation or deletion. Another significant patent is related to death receptors as markers for rhTRAIL-sensitivity. This invention discloses methods and compositions for identifying and treating specific conditions and diseases. The inventive concepts provide methods for determining rhTRAIL sensitivity of a sample and compositions for inducing apoptosis to treat various conditions.

Career Highlights

Kalafatis has had a distinguished career, working at reputable institutions such as Cleveland State University and the University of Vermont and State Agricultural College. His work has not only contributed to academic knowledge but has also had practical applications in medical treatments.

Collaborations

Throughout his career, Kalafatis has collaborated with esteemed colleagues, including Kenneth G Mann and Joseph Wiencek. These partnerships have further enriched his research and innovations.

Conclusion

Michael Kalafatis stands out as a prominent inventor in the field of biotechnology. His innovative patents and contributions to medical science reflect his dedication to improving health outcomes. His work continues to inspire future advancements in the industry.