The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2021
Filed:
Oct. 07, 2016
Applicant:
Cleveland State University, Cleveland, OH (US);
Inventors:
Michael Kalafatis, Shaker Heights, OH (US);
Joseph Wiencek, Cleveland, OH (US);
Assignee:
Cleveland State University, Cleveland, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/74 (2006.01); A61P 7/02 (2006.01); A61K 38/48 (2006.01); C12N 15/79 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6429 (2013.01); A61K 38/4833 (2013.01); A61P 7/02 (2018.01); C12N 15/79 (2013.01); C12Y 304/21005 (2013.01); A61K 38/00 (2013.01);
Abstract
During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.