Michael Dalziel

Title: The Innovative Contributions of Michael Dalziel: A Patent Profile

Introduction: Michael Dalziel, an accomplished inventor based in South San Francisco, California, has made significant strides in the field of pharmaceutical innovations. With a total of three patents to his name, Dalziel's work focuses on novel synthesis processes and compounds that have the potential to impact cancer treatment significantly.

Latest Patents: Among his latest patents is the synthesis of a bis-mesylate salt of 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. This innovative manufacturing process includes several key reactions, such as a robust and scalable palladium-catalyzed carbonylation reaction and a highly chemoselective platinum/vanadium/catalyzed nitro group reduction. The final amide coupling of the intermediates is accomplished using N,N,N',N′-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent. The resulting compound is produced with high yield, purity, and form stability, meeting industry standards for multikilogram production scales.

Dalziel's other notable patent involves solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol. This patent details processes for preparing fused tricyclic compounds with therapeutic applications in cancer treatment.

Career Highlights: Michael Dalziel has built an impressive career in the pharmaceutical industry, having worked for prominent companies such as Genentech, Inc. and Hoffmann-La Roche Inc. His extensive experience in research and development has culminated in patented processes that enhance the efficiency of drug manufacturing.

Collaborations: Throughout his career, Dalziel has collaborated with notable coworkers such as Francis Gosselin and Haiming Zhang. These partnerships emphasize the importance of teamwork and collaboration in advancing scientific research and obtaining patents.

Conclusion: Michael Dalziel's innovative contributions to the field of pharmaceutical chemistry demonstrate the critical role of inventors in developing effective treatments for diseases such as cancer. His patents reflect a commitment to improving drug synthesis processes, positioning him as a key player in the ongoing fight against cancer.