The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 10, 2023

Filed:

Dec. 03, 2020
Applicants:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Cheol Keun Chung, South San Francisco, CA (US);

Jie Xu, South San Francisco, CA (US);

Hans Iding, Basel, CH;

Kyle Clagg, South San Francisco, CA (US);

Michael Dalziel, South San Francisco, CA (US);

Alec Fettes, Basel, CH;

Francis Gosselin, South San Francisco, CA (US);

Ngiap-Kie Lim, South San Francisco, CA (US);

Andrew McClory, South San Francisco, CA (US);

Haiming Zhang, South San Francisco, CA (US);

Paroma Chakravarty, South San Francisco, CA (US);

Karthik Nagapudi, South San Francisco, CA (US);

Sarah Robinson, South San Francisco, CA (US);

Assignees:

Genentech, Inc., South San Francisco, CA (US);

Hoffmann-La Roche Inc., Little Falls, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 403/14 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 403/14 (2013.01); C07B 2200/13 (2013.01);
Abstract

Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.


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