Location History:
- Owings Mill, MD (US) (1997 - 1999)
- Chapel Hill, NC (US) (2014)
- Cordova, TN (US) (2002 - 2015)
Company Filing History:
7 out of 260 
1 out of 13 
1 out of 3,682 
Years Active: 1997-2015
Title: Michael B. Kastan - Innovator in Cancer Research
Introduction
Michael B. Kastan, based in Cordova, TN, is a prominent inventor and researcher known for his significant contributions to the field of cancer biology. With an impressive portfolio of 11 patents, he has focused his work on the regulation of the p53 tumor suppressor protein, which plays a critical role in cellular response to stress and tumorigenesis.
Latest Patents
Among his latest patents, Kastan has developed innovative methods for the regulation of p53 translation and function. This invention addresses novel ways to modulate the activity of the p53 protein by influencing its translational regulation through interactions with key proteins, including Ribosomal Protein L26 (RPL26) and nucleolin. These methods hold potential therapeutic applications in treating cancer, neurodegenerative disorders, and minimizing the adverse effects of cellular stresses.
Another notable patent involves the creation of oligonucleotides that inhibit p53 induction during cellular stress. These oligonucleotides, comprising specific p53 5'-UTR and 3'-UTR sequences, can be utilized in therapeutic applications such as protecting normal tissues from the toxicities of chemical exposure, reducing tissue damage in various medical conditions, and even preserving tissues and organs prior to transplantation.
Career Highlights
Kastan has contributed significantly to research environments, particularly at St. Jude Children's Research Hospital. His tenure there has fostered groundbreaking work in understanding the mechanisms of p53 and its implications for cancer therapy and treatment of various disorders.
Collaborations
Throughout his career, Michael B. Kastan has collaborated with distinguished colleagues, including Christopher Bakkenist and Christine Canman. These partnerships not only highlight his commitment to advancing scientific knowledge but also demonstrate his ability to work collaboratively with other experts in related fields.
Conclusion
In summary, Michael B. Kastan is a key inventor whose innovations are shaping the future of cancer treatment and cellular biology. With a robust patent portfolio and meaningful collaborations, he continues to influence the landscape of medical research, striving to foster new therapeutic avenues for challenging health issues. His work exemplifies the intersection of innovation and science, paving the way for advancements that can have a lasting impact on patient care.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.